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Erectile Dysfunction Drugs could help Treat Oesophageal Cancer, Study Finds

Erectile dysfunction drugs might assist deal with oesophageal cancer, research study finds

22 June 2022

An ingredient in impotence medication may assist deal with oesophageal cancer, a study has discovered.

Southampton scientists found the PDE5 inhibitors in the medication assisted penetrate the barrier of cells around tumours, enabling chemotherapy drugs to reach cancer cells.

One in 10 patients currently survives the illness, which is discovered anywhere in the craw, for 10 years or more.

The study was funded by Cancer Research UK. The next stage is a scientific trial.

Prof Tim Underwood, lead author of the research study, stated the discovery could enhance these survival rates.

He stated a cell known as the cancer-associated fibroblast, for wound healing, could be targeted with the inhibitors.

“It’s been utilized throughout the world in millions of doses,” he explained. “It’s safe, and we used it to cancer.”

He added it was to the scientists “amazement and surprise and delight” that the drug had an impact.

“We need to put this into a medical trial where we try the drug type alongside chemotherapy to see if it makes the chemotherapy more reliable,” he said.

“The initial work recommends it needs to do, and if it does and if it’s safe, and it improves results of chemotherapy, then it could be actually substantial for the patients I care for.”

The research study was performed using tumours from eight cancer clients, with additional tests done on mice.

Chemotherapy just helps 20% of oesophageal cancer patients in a substantial method, he stated.

“If this drug mix even improves it by a percentage, we’re really going to help a a great deal of people every year to react better and live longer.”

Researchers at Southampton University Hospitals state that the normal outcomes of erectile dysfunction condition drugs require extra stimulation, so would not affect cancer patients in the same method.

Prof Underwood said the main adverse effects would be “a bit of headache, a little bit of flushing”.

Terry Daly, from Aldershot, Hampshire, is among the 9,500 individuals identified with oesophageal cancer in the UK every year.

It often goes unnoticed in the early phases, with Mr Daly finding it was hard to swallow his food and he ended up regurgitating it.

He is shortly to undergo another round of chemotherapy, and stated if he had the choice to take the new treatment he would have “taken it with both hands”.

“The research that is being done is definitely wonderful,” he stated.

“It is simply extraordinary that there are individuals out there happy to spend their lives simply looking for a remedy, so that individuals can proceed with their everyday lives and not need to go through all this stuff.

“You can’t thank these individuals enough for what they’re doing.”

The five-year study has actually been moneyed by Cancer Research UK and the Medical Research Council.

A scientific trial is expected within the next 18 months and if effective, it is hoped brand-new treatments based on this research study could be used within ten years.

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Related topics

Aldershot

Southampton

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Related internet links

Cancer Research UK

University Hospital Southampton

Institute of Developmental Sciences – University of Southampton

What is oesophageal cancer? – NHS

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